AFC is a three-letter abbreviation with multiple meanings, as described below:

• Automatic Fare Collection
• Aberdeen Football Club
• Air Force Cross
• Alabama Forestry Commission
• Alkaline fuel cell
• America First Committee
• American Football Conference of the National Football League
• Arsenal Football Club
• Asian Football Confederation
• Association Football Club or Athletics and Football Club
• Australian Flying Corps
• Automatic Fine Tuning Control
• Automatic Frequency Control, circuit that locks a TV or FM receiver to the station frequency.
• Away from computer
• Average fixed cost
• Asian Financial Crisis
• Average Frustrated Chump, an average, clueless nice guy, according to alt.seduction.fast. See also: Nice guy syndrome.